Learn the typical dosages of fluoxetine (Prozac) for depression, OCD, and panic disorder. Find details on available strengths (10mg, 20mg, 40mg), daily timing, and what to do if you miss a dose. Adult dose: Treatment starts at 20 mg once daily in the morning and may be increased after several weeks if there is a lack of clinical improvement. The recommended dose range is 20 mg to 60 mg per day. For major depressive disorder and OCD in adults, start fluoxetine at 20 mg daily and increase by 20 mg increments after several weeks if needed, with doses administered once daily in the morning or split into morning and noon dosing for amounts above 20 mg. 1 Prozac (fluoxetine) can treat certain mental health conditions. A typical Prozac dose is 20 mg daily at first. Your healthcare provider may recommend a greater amount. Find patient medical information for Fluoxetine (Prozac, Sarafem, others) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings The dosage of Prozac (fluoxetine) may vary based on your age and the condition it’s used to treat. The typical starting dosage ranges from 10 to 60 milligrams (mg) per day. Detailed Fluoxetine dosage information for adults and children. Includes dosages for Depression, Panic Disorder, Obsessive Compulsive Disorder and more; plus renal, liver and dialysis adjustments. However, the dose is usually not more than 50 mg of fluoxetine and 12 mg of olanzapine per day. Children younger than 10 years of age—Use and dose must be determined by your doctor. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) and does not appreciably inhibit norepinephrine and dopamine reuptake at therapeutic doses. It does, however, delay the reuptake of serotonin, resulting in serotonin persisting longer when it is released. Indicated for acute and maintenance treatment of major depressive disorder (MDD) Initial: 20 mg PO qDay. May consider gradually increasing dose after several weeks by 20 mg/day; not to exceed 80.